From Proteopedia
proteopedia linkproteopedia link Interactions between the Ribosome and Antibiotics
A major class of antibiotics are those that target protein synthesis.
Given the numerous solved structures of antibiotics complexed with ribosomes and ribosomal subunits and the massive size and complexity of the ribosome and the files derived from each structure, several technical and pedagogical issues are obstacles appreciating the elegance and insight provided by these structures. Towards that end this package of pages feature:
- Consistent representation and color scheme for the ribosomal subunits, elements and ligands enabling easy visualization of a particular antibiotic binds.
- Links to Proteopedia pages covering the essentials of the structures of each subunit and complete ribosome.
- Data optimized for viewing online in Jmol. This includes limiting much of the files to simply alpha carbon and phosphate atoms and, significantly, combining data split split across multiple PDB coordinate files so the entire ribosome structure is visible at once, an issue the RCSB Protein Data Bank has recently attempted to address, as described here.
Pages for the Antibiotics bound to the Ribosome
Additional Literature and Resources
