3jy9
From Proteopedia
Contents |
Janus Kinase 2 Inhibitors
Template:ABSTRACT PUBMED 20014869
Disease
Known disease associated with this structure: Leukemia, acute myelogenous OMIM:[147796], Myelofibrosis, idiopathic OMIM:[147796], Myeloproliferative disorder with erythrocytosis OMIM:[147796], Polycythemia vera OMIM:[147796], Thrombocythemia, essential OMIM:[147796], Budd-Chiari syndrome OMIM:[147796]
About this Structure
3JY9 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Wang T, Duffy JP, Wang J, Halas S, Salituro FG, Pierce AC, Zuccola HJ, Black JR, Hogan JK, Jepson S, Shlyakter D, Mahajan S, Gu Y, Hoock T, Wood M, Furey BF, Frantz JD, Dauffenbach LM, Germann UA, Fan B, Namchuk M, Bennani YL, Ledeboer MW. Janus kinase 2 inhibitors. Synthesis and characterization of a novel polycyclic azaindole. J Med Chem. 2009 Dec 24;52(24):7938-41. PMID:20014869 doi:10.1021/jm901383u
Page seeded by OCA on Wed Dec 30 14:05:18 2009
Categories: Homo sapiens | Non-specific protein-tyrosine kinase | Ledeboer, M W. | Pierce, A C. | Zuccola, H J. | Atp-binding | Chromosomal rearrangement | Disease mutation | Inhibitor | Jak2 | Janus kinase | Kinase | Membrane | Nucleotide-binding | Phosphoprotein | Polymorphism | Proto-oncogene | Sh2 domain | Transferase | Tyrosine-protein kinase
