3frd

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Image:3frd.jpg

Template:STRUCTURE 3frd

S. aureus DHFR complexed with NADPH and folate

Template:ABSTRACT PUBMED 19211577

About this Structure

3FRD is a 1 chain structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

  • Oefner C, Bandera M, Haldimann A, Laue H, Schulz H, Mukhija S, Parisi S, Weiss L, Lociuro S, Dale GE. Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity. J Antimicrob Chemother. 2009 Apr;63(4):687-98. Epub 2009 Feb 11. PMID:19211577 doi:10.1093/jac/dkp024

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