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1k4r
From Proteopedia
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| 1k4r, resolution 24.00Å () | |||||||||
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| Related: | 1svb | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Structure of Dengue Virus
The first structure of a flavivirus has been determined by using a combination of cryoelectron microscopy and fitting of the known structure of glycoprotein E into the electron density map. The virus core, within a lipid bilayer, has a less-ordered structure than the external, icosahedral scaffold of 90 glycoprotein E dimers. The three E monomers per icosahedral asymmetric unit do not have quasiequivalent symmetric environments. Difference maps indicate the location of the small membrane protein M relative to the overlaying scaffold of E dimers. The structure suggests that flaviviruses, and by analogy also alphaviruses, employ a fusion mechanism in which the distal beta barrels of domain II of the glycoprotein E are inserted into the cellular membrane.
Structure of dengue virus: implications for flavivirus organization, maturation, and fusion., Kuhn RJ, Zhang W, Rossmann MG, Pletnev SV, Corver J, Lenches E, Jones CT, Mukhopadhyay S, Chipman PR, Strauss EG, Baker TS, Strauss JH, Cell. 2002 Mar 8;108(5):717-25. PMID:11893341
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1K4R is a 3 chains structure with sequences from Viruses. The July 2008 RCSB PDB Molecule of the Month feature on Dengue Virus by David Goodsell is 10.2210/rcsb_pdb/mom_2008_7. Full crystallographic information is available from OCA.
Reference
- Kuhn RJ, Zhang W, Rossmann MG, Pletnev SV, Corver J, Lenches E, Jones CT, Mukhopadhyay S, Chipman PR, Strauss EG, Baker TS, Strauss JH. Structure of dengue virus: implications for flavivirus organization, maturation, and fusion. Cell. 2002 Mar 8;108(5):717-25. PMID:11893341
Page seeded by OCA on Wed Jan 20 22:41:41 2010
Categories: Dengue Virus | RCSB PDB Molecule of the Month | Viruses | Baker, T S. | Chipman, P R. | Corver, J. | Jones, C T. | Kuhn, R J. | Lenches, E. | Mukhopadhyay, S. | Pletnev, S V. | Rossmann, M G. | Strauss, E G. | Strauss, J H. | Zhang, W. | Dengue virus | Flaviviridae | Flavivirus | Glycoprotein e from tick-borne encephalitis virus | Icosahedral virus
