4cox

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Image:4cox.png

Template:STRUCTURE 4cox

CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) COMPLEXED WITH A NON-SELECTIVE INHIBITOR, INDOMETHACIN

Template:ABSTRACT PUBMED 8967954

About this Structure

4COX is a 4 chains structure with sequences from Mus musculus. The May 2001 RCSB PDB Molecule of the Month feature on Cyclooxygenase by David S. Goodsell is 10.2210/rcsb_pdb/mom_2001_5. Full crystallographic information is available from OCA.

Reference

  • Kurumbail RG, Stevens AM, Gierse JK, McDonald JJ, Stegeman RA, Pak JY, Gildehaus D, Miyashiro JM, Penning TD, Seibert K, Isakson PC, Stallings WC. Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. Nature. 1996 Dec 19-26;384(6610):644-8. PMID:8967954 doi:http://dx.doi.org/10.1038/384644a0

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