2zvt

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Image:2zvt.png

Template:STRUCTURE 2zvt

Contents

Cys285Ser mutant PPARgamma ligand-binding domain complexed with 15-deoxy-delta12,14-prostaglandin J2

Template:ABSTRACT PUBMED 19101554

Disease

Known disease associated with this structure: Carotid intimal medial thickness 1 OMIM:[601487], Insulin resistance, severe, digenic OMIM:[601487], Lipodystrophy, familial partial, type 3 OMIM:[601487], Obesity, severe OMIM:[601487], Obesity, resistance to OMIM:[601487], Diabetes, type 2 OMIM:[601487], Glioblastoma, susceptibility to OMIM:[601487]

About this Structure

2ZVT is a 2 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Waku T, Shiraki T, Oyama T, Morikawa K. Atomic structure of mutant PPARgamma LBD complexed with 15d-PGJ2: novel modulation mechanism of PPARgamma/RXRalpha function by covalently bound ligands. FEBS Lett. 2009 Jan 22;583(2):320-4. Epub 2008 Dec 26. PMID:19101554 doi:10.1016/j.febslet.2008.12.017

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