2wks

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Image:2wks.png

Template:STRUCTURE 2wks

STRUCTURE OF HELICOBACTER PYLORI TYPE II DEHYDROQUINASE WITH A NEW CARBASUGAR-THIOPHENE INHIBITOR.

Template:ABSTRACT PUBMED 19911771

About this Structure

2WKS is a 6 chains structure with sequences from Helicobacter pylori. Full crystallographic information is available from OCA.

Reference

  • Prazeres VF, Tizon L, Otero JM, Guardado-Calvo P, Llamas-Saiz AL, van Raaij MJ, Castedo L, Lamb H, Hawkins AR, Gonzalez-Bello C. Synthesis and Biological Evaluation of New Nanomolar Competitive Inhibitors of Helicobacter pylori Type II Dehydroquinase. Structural Details of the Role of the Aromatic Moieties with Essential Residues (double dagger). J Med Chem. 2009 Nov 13. PMID:19911771 doi:10.1021/jm9010466
  • Gonzalez-Bello C, Castedo L. Progress in type II dehydroquinase inhibitors: from concept to practice. Med Res Rev. 2007 Mar;27(2):177-208. PMID:17004270 doi:10.1002/med.20076
  • Sanchez-Sixto C, Prazeres VF, Castedo L, Suh SW, Lamb H, Hawkins AR, Canada FJ, Jimenez-Barbero J, Gonzalez-Bello C. Competitive inhibitors of Helicobacter pylori type II dehydroquinase: synthesis, biological evaluation, and NMR studies. ChemMedChem. 2008 May;3(5):756-70. PMID:18200648 doi:10.1002/cmdc.200700307

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