Fructose Bisphosphate Aldolase
From Proteopedia
Fructose biphosphate aldolase Fructose biphosphate aldolase is an enzyme in glycolysis. It catalyzes the breakdown of fructose-1,6-biophosphate into dihydroxyacetone phosphate (DHAP) and glyceraldehyde-2-phosphate (GAP). The reaction is an aldol cleavage, or otherwise termed, retro aldo condensation. Catalysis occurs by the formation of a Schiff base (an imine resulting from a ketone and amine) from the amine of the aldolase's Lys229 and the open-ring form of FBP accompanied by stabilization from Asp33. [1]
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Austin Drake, David Canner, Jacob Holt, Alexander Berchansky, Michal Harel
