Cory Tiedeman Sandbox 1

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spinqualitylabelsall models PDB ID 1one Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1one, resolution 1.80Å ()
Ligands:	,
Non-Standard Residues:
Activity:	Phosphopyruvate hydratase, with EC number 4.2.1.11
Structural annotation: Resources: CATH : 1Onea01, 1Onea02, 1Oneb02, 1Oneb01 InterPro : Ipr000941 Pfam : PF03952, PF00113 SCOP : d1onea1, d1onea2, d1oneb1, d1oneb2 UniProt : P00924
Functional annotation: Cellular component: cytoplasm vacuole, cell cycle-correlated morphology phosphopyruvate hydratase complex mitochondrion Biological process: regulation of vacuole fusion, non-autophagic glycolysis gluconeogenesis Molecular function: protein binding phosphopyruvate hydratase activity metal ion binding lyase activity magnesium ion binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

Enolase is an enzyme that catalyzes a reaction of glycolysis. Glycolysis converts glucose into two 3-carbon molecules called pyrubate. The energy released during glycolysis is used to make ATP.^[1] Enolase is used to convert2-phosphoglycerate (2PG) to phosphoenolpyruvate (PEP) in the 9th reaction of glycolysis.^[2]

Structure

Structural Clasification of Proteins (SCOP) Class: alpha and beta proteins (a/b)

Fold: TIM beta/alpha-barrel

Superfamily: Enolase C-terminal domain-like

Family: Enolase

Species: Baker's yeast (Saccharomyces cerevisiae)

Mechanism

The of enolase as shown, involves Lys 345, Lys 396, Glu 168, Glu 211, and His 159.

References