Birrer Sandbox 2

From Proteopedia

Alcohol Dehydrogenase

spinqualitylabelsall models PDB ID 1htb Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1htb, resolution 2.40Å ()
Ligands:	, , ,
Gene:	HUMAN BETA3 CDNA (Homo sapiens)
Activity:	Alcohol dehydrogenase, with EC number 1.1.1.1
Structural annotation: Resources: CATH : 1Htba01, 1Htba02, 1Htbb02, 1Htbb01 InterPro : Ipr013149, Ipr002328, Ipr011032, Ipr013154, Ipr002085 Pfam : PF00107, PF08240 SCOP : d1htba1, d1htba2, d1htbb2, d1htbb1 UniProt : P00325
Functional annotation: Cellular component: cytoplasm Biological process: ethanol oxidation Molecular function: metal ion binding alcohol dehydrogenase activity, zinc-dependent electron carrier activity oxidoreductase activity alcohol dehydrogenase activity zinc ion binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

Alcohol dehydrogenase (ADH) is an enzyme that catalyzes the oxidation of primary and secondary alcohols to their corresponding aldehydes and ketones through a mechanism that involves the removal of hydrogen. In the oxidation mechanism, ADH is momentarily associated with nicontinamide adenine dinucleotide (NAD+), which functions as a cosubstrate. The reaction is shown below: CH3CH2OH + NAD+ -> CH3COH (acetaldehyde) + NADH + H+ (Note: The reaction is actually reversible although the arrow does not show it) ^[1]