3kn2

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Image:3kn2.png

Template:STRUCTURE 3kn2

HCV NS3 Protease Domain with ketoamide inhibitor

Template:ABSTRACT PUBMED 20004570

About this Structure

3KN2 is a 4 chains structure with sequences from Hepatitis c virus subtype 1a. Full crystallographic information is available from OCA.

Reference

  • Nair LG, Sannigrahi M, Bogen S, Pinto P, Chen KX, Prongay A, Tong X, Cheng KC, Girijavallabhan V, George Njoroge F. P4 capped amides and lactams as HCV NS3 protease inhibitors with improved potency and DMPK profile. Bioorg Med Chem Lett. 2010 Jan 15;20(2):567-70. Epub 2009 Nov 22. PMID:20004570 doi:10.1016/j.bmcl.2009.11.094

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