3fcs

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Image:3fcs.png

Template:STRUCTURE 3fcs

Contents

Structure of complete ectodomain of integrin aIIBb3

Template:ABSTRACT PUBMED 19111664

Disease

Known disease associated with this structure: Glanzmann thrombasthenia, type A OMIM:[607759], Thrombocytopenia, neonatal alloimmune OMIM:[607759]

About this Structure

3FCS is a 4 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Zhu J, Luo BH, Xiao T, Zhang C, Nishida N, Springer TA. Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces. Mol Cell. 2008 Dec 26;32(6):849-61. PMID:19111664 doi:10.1016/j.molcel.2008.11.018

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