3l8x

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Image:3l8x.jpg

Template:STRUCTURE 3l8x

P38 alpha kinase complexed with a pyrazolo-pyrimidine based inhibitor

Template:ABSTRACT PUBMED 18359226

About this Structure

3L8X is a 1 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 3cg2. Full crystallographic information is available from OCA.

Reference

  • Das J, Moquin RV, Pitt S, Zhang R, Shen DR, McIntyre KW, Gillooly K, Doweyko AM, Sack JS, Zhang H, Kiefer SE, Kish K, McKinnon M, Barrish JC, Dodd JH, Schieven GL, Leftheris K. Pyrazolo-pyrimidines: a novel heterocyclic scaffold for potent and selective p38 alpha inhibitors. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2652-7. Epub 2008 Mar 10. PMID:18359226 doi:10.1016/j.bmcl.2008.03.019

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