Apurinic-Apyrimidinic Endonuclease

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Contents

APURINIC/APYRIMIDINIC ENDONUCLEASE-1 (APE1)

INTRODUCTION

APE1 is an endonuclease [1].

Image:APE!.png


Image:Png













STRUCTURE AND FUNCTION

APE1 works in the base excision repair pathway

APE interacting with DNA

Drag the structure with the mouse to rotate
Image:BERpath.png



Image:APEmech.png
Image:APEactivesite.png

















POPULATION VARIENTS

APE1 HAS BEEN SHOWN TO CLEAVE C-MYC MRNA



























REFERENCES

  1. ↑ Barnes,T
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