Pilin
From Proteopedia
Contents |
Salmonella typhi type IVb pilin (PilS)
Introduction
Type IV pili play an important role in the pathogenesis of many bacterial species; they are a required component for the adhesion of bacteria to their target cells. They may also mediate transformation, modulate target-cell specificity and play a role in twitching motility [1]. The type IVb pilus of Salmonella typhi is the adhesion factor that allows the pathogen to enter into the gastrointestinal cells of animals [2].
Structure
Type IV pilin are homopolymers, composed of a single-chain pilin protein.
Function
References
- ↑ Asha M. Balakrishna,Yvonne Yih-Wan Tan, Henry Yu-Keung Mok,Anand M. Saxena,and Kunchithapadam Swaminathan. Crystallization and preliminary X-ray diffraction analysis of Salmonella typhi PilS. 2006 October 1; 62(Pt 10): 1024–1026
- ↑ Balakrishna AM, Saxena AM, Mok HY, Swaminathan K. Structural basis of typhoid: Salmonella typhi type IVb pilin (PilS) and cystic fibrosis transmembrane conductance regulator interaction. Proteins. 2009 Nov 1;77(2):253-61. PMID:19626704 doi:10.1002/prot.22500
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