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Contents 1 Salmonella typhi type IVb pilin (PilS) 2 Introduction 3 Structure 4 Function 5 References

Salmonella typhi type IVb pilin (PilS)

Introduction

Type IV pili play an important role in the pathogenesis of many bacterial species; they are a required component for the adhesion of bacteria to their target cells. For example, Type IV pili is required for infection by the pathogens that cause cholera, typhoid, pneumonia, gonorrhea, and meningitis ^[1]. They may also mediate transformation, modulate target-cell specificity and play a role in twitching motility ^[2]. Specifically, the type IVb pilus of Salmonella typhi is the adhesion factor that allows the pathogen to enter into the gastrointestinal cells of animals ^[1].

Structure

Type IV pilin are homopolymers, composed of a single-chain pilin protein ^[1].

Function

References

1. ↑ ^{1.0 1.1 1.2} Balakrishna AM, Saxena AM, Mok HY, Swaminathan K. Structural basis of typhoid: Salmonella typhi type IVb pilin (PilS) and cystic fibrosis transmembrane conductance regulator interaction. Proteins. 2009 Nov 1;77(2):253-61. PMID:19626704 doi:10.1002/prot.22500
2. ↑ Asha M. Balakrishna,Yvonne Yih-Wan Tan, Henry Yu-Keung Mok,Anand M. Saxena,and Kunchithapadam Swaminathan. Crystallization and preliminary X-ray diffraction analysis of Salmonella typhi PilS. 2006 October 1; 62(Pt 10): 1024–1026