Sandbox 172

From Proteopedia

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Hexokinase Type I

Hexokinase Type I is one of four hexokinase isoenzymes that participate in glycolysis. Hexokinase catalyzes the phosphorylation of glucose into glucose-6-phosphate (G6P) providing enough activation energy for the glycolytic process to start. Thus hexokinase allows the muscle cells to take up glucose in the blood and use it as an energy source for different actions and expenditures. Hexokinase Type I is mainly found in mammalian tissues; it is crucial enzyme in maintaining a downward concentration gradient to provide a steady influx of glucose into cells.

spinqualitylabelsall models PDB ID 1cza Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1cza, resolution 1.90Å ()
Ligands:	, ,
Activity:	Hexokinase, with EC number 2.7.1.1
Related:	1hkb, 1hkc
Structural annotation: Resources: CATH : 1Czan02, 1Czan01, 1Czan04, 1Czan03 InterPro : Ipr001312 Pfam : PF00349, PF03727 SCOP : d1czan1, d1czan3, d1czan4, d1czan2 UniProt : P19367
Functional annotation: Cellular component: membrane mitochondrion Biological process: glycolysis Molecular function: nucleotide binding kinase activity catalytic activity transferase activity hexokinase activity ATP binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Introduction

Four types of hexokinase isozymes exist in the human biological system. They all serve to catalyze the exact same reaction in glycolysis even though they are encoded by different sets of genes. The hexokinase types I-III all have a high affinity for glucose and become subject to inhibition in the presence of glucose-6-phosphate- the first step reaction product in glycolysis. Hexokinase type IV varies from the other three hexokinase types as it is not inhibited by the production of glucose-6-phosphate and shows a lower affinity for glucose.

Adrienne Lam

This is the of the protein.

Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. Andrea Gorrell.