Glycolysis Enzymes

From Proteopedia

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The Enzymes of Glycolysis

Glycolysis is a key metabolic pathway for organisms. In it, glucose is converted into two pyruvate molecules. The process includes ten enzymes, described in further detail on the linked pages.

The first phase of glycolysis is sometimes referred to as the "investment phase", where ATP is consumed to set up later, energy generating steps. The first step of the pathway is the conversion of glucose to glucose-6-phosphate by either hexokinase or glucokinase. Glucose-6-phosphate isomerizes to fructose-6-phosphate; this reaction is catalyzed by phosphoglucoisomerase. This isomerization allows for the creation of two, three carbon sugars as a product. Phosphofructokinase catalyzes the second phosphorylation reaction, and is the most highly regulated step of the pathway.