1hjz

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1hjz, resolution 1.7Å

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CRYSTAL STRUCTURE OF AF1521 PROTEIN CONTAINING A MACROH2A DOMAIN

Overview

MacroH2A is an unusual histone H2A variant that has an extensive, C-terminal tail that comprises approximately two thirds of the protein., The C-terminal non-histone domain of macroH2A is also found in a number of, other proteins and has been termed the macro domain. Here we report the, crystal structure to 1.7A of AF1521, a protein consisting of a stand-alone, macro domain from Archaeoglobus fulgidus. The structure has a mixed, alpha/beta fold that closely resembles the N-terminal DNA binding domain, of the Escherichia coli leucine aminopeptidase PepA. The structure also, shows some similarity to members of the P-loop family of nucleotide, hydrolases.

About this Structure

1HJZ is a Single protein structure of sequence from Archaeoglobus fulgidus with MES as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.

Reference

The crystal structure of AF1521 a protein from Archaeoglobus fulgidus with homology to the non-histone domain of macroH2A., Allen MD, Buckle AM, Cordell SC, Lowe J, Bycroft M, J Mol Biol. 2003 Jul 11;330(3):503-11. PMID:12842467

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