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1gwz
From Proteopedia
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTEIN TYROSINE PHOSPHATASE SHP-1
Overview
The crystal structures of the protein-tyrosine phosphatase SHP-1 catalytic, domain and the complex it forms with the substrate analogue tungstate have, been determined and refined to crystallographic R values of 0.209 at 2.5 A, resolution and 0.207 at 2.8 A resolution, respectively. Despite low, sequence similarity, the catalytic domain of SHP-1 shows high similarity, in secondary and tertiary structures with other protein-tyrosine, phosphatases (PTPs). In contrast to the conformational changes observed in, the crystal structures of PTP1B and Yersinia PTP, the WPD loop, (Trp419-Pro428) in the catalytic domain of SHP-1 moves away from the, substrate binding pocket after binding the tungstate ion. Sequence, alignment and structural analysis suggest that the residues in the WPD, loop, ... [(full description)]
About this Structure
1GWZ is a [Single protein] structure of sequence from [Homo sapiens]. Active as [Protein-tyrosine-phosphatase], with EC number [3.1.3.48]. Structure known Active Site: WPD. Full crystallographic information is available from [OCA].
Reference
Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1., Yang J, Liang X, Niu T, Meng W, Zhao Z, Zhou GW, J Biol Chem. 1998 Oct 23;273(43):28199-207. PMID:9774441
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