Yadilette Rivera-Colon/sandbox1

From Proteopedia

Vitronectin

Vitronectin is a glycoprotein found in the ECM and promotes cell adhesion and spreading. It has been shown to be implicated in hemostasis [1] and tumor growth [2]. Vitronectin regulates proteolysis initiated by plasminogen activation. It interacts with the urokinase receptor through its Somatomedin B (SMB) domain, and this interaction has been implicated in cell migration and signal transduction. Vitronectin contains an Arginine, Glutamine, Aspartic acid (RGD) sequence that is a binding site for membrane bound integrins, which provides an anchor for cells to the ECM. High plasma levels of both PAI-1 and the urokinase receptor have been shown to correlate with a negative prognosis for cancer patients.

spinqualitylabelsall models PDB ID 1oc0 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1oc0, resolution 2.28Å ()
Related:	1a7c, 1b3k, 1c5g, 1db2, 1dvm, 1dvn, 1lj5, 9pai
Structural annotation: Resources: CATH : 1Oc0A02, 1Oc0A01 InterPro : Ipr000215, Ipr001212, Ipr000585 Pfam : PF00079, PF01033 SCOP : d1oc0a_, d1oc0b_ UniProt : P05121, P04004
Functional annotation: Cellular component: extracellular region extracellular space proteinaceous extracellular matrix Biological process: blood coagulation regulation of angiogenesis fibrinolysis cell adhesion immune response cell-matrix adhesion Molecular function: protein binding endopeptidase inhibitor activity protease binding plasminogen activator activity serine-type endopeptidase inhibitor activity metal ion binding heparin binding catalytic activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml