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Factor Xa
From Proteopedia
Contents |
Introduction
Factor X is a vitamin K-dependent glycoprotein that is synthesized in the liver. Zymogen factor X circulates in plasma as a 2 chain molecule composed of a disulfide linked light chain (Mr = 16500) and heavy chain (Mr = 42,000). Factor X is activated to factor Xa by cleavage of the activation peptide. This reaction is catalyzed by factor VIIa-tissue factor (extrinsic Xase complex) and factor IXa-factor VIIIa (intrinsic Xase complex).
Factor Xa, along with factor Va, calcium, and a phospholipid membrane surface form the prothrombinase complex, to cleave prothrombin to its active form, thrombin.
Structure
Enzyme Mechanism
General Serine Protease Mechanism
Related Enzymes
Proteopedia Page Contributors and Editors (what is this?)
Jacqueline Gertz, Michal Harel, Alexander Berchansky, David Canner, Jaime Prilusky
