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3ho5

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Image:3ho5.png

Template:STRUCTURE 3ho5

Contents

Crystal structure of Hedgehog-interacting protein (HHIP) and Sonic hedgehog (SHH) complex

Template:ABSTRACT PUBMED 19561609

Disease

Known disease associated with this structure: Coloboma, ocular OMIM:[600725], Holoprosencephaly-3 OMIM:[600725], Microphthalmia, isolated, with coloboma 5 OMIM:[600725], Solitary median maxillary central incisor OMIM:[600725]

About this Structure

3HO5 is a 3 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Bosanac I, Maun HR, Scales SJ, Wen X, Lingel A, Bazan JF, de Sauvage FJ, Hymowitz SG, Lazarus RA. The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling. Nat Struct Mol Biol. 2009 Jul;16(7):691-7. Epub 2009 Jun 28. PMID:19561609 doi:10.1038/nsmb.1632

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