3l95

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Image:3l95.png

Template:STRUCTURE 3l95

Crystal structure of the human Notch1 Negative Regulatory Region (NRR) bound to the fab fragment of an antagonist antibody

Template:ABSTRACT PUBMED 20393564

About this Structure

3L95 is a 6 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Wu Y, Cain-Hom C, Choy L, Hagenbeek TJ, de Leon GP, Chen Y, Finkle D, Venook R, Wu X, Ridgway J, Schahin-Reed D, Dow GJ, Shelton A, Stawicki S, Watts RJ, Zhang J, Choy R, Howard P, Kadyk L, Yan M, Zha J, Callahan CA, Hymowitz SG, Siebel CW. Therapeutic antibody targeting of individual Notch receptors. Nature. 2010 Apr 15;464(7291):1052-7. PMID:20393564 doi:10.1038/nature08878

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