3l8v

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Template:STRUCTURE 3l8v

Contents 1 Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with a biarylamine based inhibitor 2 Disease 3 About this Structure 4 Reference

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with a biarylamine based inhibitor

Template:ABSTRACT PUBMED 20382527

Disease

Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[164860], Renal cell carcinoma, papillary, familial and sporadic OMIM:[164860], Autism, suseptibility to, 9 OMIM:[164860]

About this Structure

3L8V is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Williams DK, Chen XT, Tarby C, Kaltenbach R, Cai ZW, Tokarski JS, An Y, Sack JS, Wautlet B, Gullo-Brown J, Henley BJ, Jeyaseelan R, Kellar K, Manne V, Trainor GL, Lombardo LJ, Fargnoli J, Borzilleri RM. Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors. Bioorg Med Chem Lett. 2010 May 1;20(9):2998-3002. Epub 2010 Jan 20. PMID:20382527 doi:10.1016/j.bmcl.2010.01.042

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