3kb7

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Image:3kb7.jpg

Template:STRUCTURE 3kb7

Crystal structure of Polo-like kinase 1 in complex with a pyrazoloquinazoline inhibitor

Template:ABSTRACT PUBMED 20397705

About this Structure

3KB7 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Beria I, Ballinari D, Bertrand JA, Borghi D, Bossi RT, Brasca MG, Cappella P, Caruso M, Ceccarelli W, Ciavolella A, Cristiani C, Croci V, De Ponti A, Fachin G, Ferguson RD, Lansen J, Moll JK, Pesenti E, Posteri H, Perego R, Rocchetti M, Storici P, Volpi D, Valsasina B. Identification of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as a new class of orally and selective Polo-like kinase 1 inhibitors. J Med Chem. 2010 May 13;53(9):3532-51. PMID:20397705 doi:10.1021/jm901713n

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