3mop

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Image:3mop.jpg

Template:STRUCTURE 3mop

Contents

The ternary Death Domain complex of MyD88, IRAK4, and IRAK2

Template:ABSTRACT PUBMED 20485341

Disease

Known disease associated with this structure: Pyogenic bacterial infections, recurrent, due to MYD88 deficiency OMIM:[602170], IRAK4 deficiency OMIM:[606883], Invasive pneumococcal disease, recurrent isolated, 1 OMIM:[606883]

About this Structure

3MOP is a 14 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Lin SC, Lo YC, Wu H. Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature. 2010 Jun 17;465(7300):885-90. Epub 2010 May 19. PMID:20485341 doi:10.1038/nature09121

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