User:Cynthia Pruss/Sandbox 1

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VWF A2 domain

spinqualitylabelsall models VWF A2 Domain PDB ID:3GXB (Zhang et al) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

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spinqualitylabelsall models Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

spinqualitylabelsall models Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

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References:

Zhang Q, Zhou YF, Zhang CZ, Zhang X, Lu C, Springer TA. Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor. Proc Natl Acad Sci U S A. 2009;106:9226-9231.

http://www.vwf.group.shef.ac.uk/ The International Society for Thrombosis and Haemostasis (ISTH)-SSC VWF Online Database has a listing of known mutations and polymorphisms.