1hki
From Proteopedia
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CRYSTAL STRUCTURE OF HUMAN CHITINASE IN COMPLEX WITH GLUCOALLOSAMIDIN B
Overview
The pseudotrisaccharide allosamidin is a potent family 18 chitinase, inhibitor with demonstrated biological activity against insects, fungi, and the Plasmodium falciparum life cycle. The synthesis and biological, properties of several derivatives have been reported. The structural, interactions of allosamidin with several family 18 chitinases have been, determined by x-ray crystallography previously. Here, a high resolution, structure of chitotriosidase, the human macrophage chitinase, in complex, with allosamidin is presented. In addition, complexes of the allosamidin, derivatives demethylallosamidin, methylallosamidin, and glucoallosamidin B, are described, together with their inhibitory properties. Similar to other, chitinases, inhibition of the human chitinase by allosamidin ... [(full description)]
About this Structure
1HKI is a [Single protein] structure of sequence from [Homo sapiens] with NAG, NA1 and ALI as [ligands]. Active as [Chitinase], with EC number [3.2.1.14]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structures of allosamidin derivatives in complex with human macrophage chitinase., Rao FV, Houston DR, Boot RG, Aerts JM, Sakuda S, van Aalten DM, J Biol Chem. 2003 May 30;278(22):20110-6. Epub 2003 Mar 14. PMID:12639956
Page seeded by OCA on Tue Oct 30 10:47:17 2007
Categories: Chitinase | Homo sapiens | Single protein | Aalten, D.M.F.Van. | Aerts, J.M.F.G. | Boot, R.G. | Houston, D.R. | Rao, F.V. | Sakuda, S. | ALI | NA1 | NAG | Allosamidin | Glucoallosamidin b | Human chitinase | Hydrolase | Structure
