3krr

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Image:3krr.jpg

Template:STRUCTURE 3krr

Crystal Structure of JAK2 complexed with a potent quinoxaline ATP site inhibitor

Template:ABSTRACT PUBMED 20587663

About this Structure

3KRR is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Baffert F, Regnier CH, De Pover A, Pissot-Soldermann C, Tavares GA, Blasco F, Brueggen J, Chene P, Drueckes P, Erdmann D, Furet P, Gerspacher M, Lang M, Ledieu D, Nolan L, Ruetz S, Trappe J, Vangrevelinghe E, Wartmann M, Wyder L, Hofmann F, Radimerski T. Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805. Mol Cancer Ther. 2010 Jul;9(7):1945-55. Epub 2010 Jun 29. PMID:20587663 doi:10.1158/1535-7163.MCT-10-0053

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