Fibrinogen

From Proteopedia

proteopedia linkproteopedia link

spinqualitylabelsall models Crystal structure of fibrinogen fragment D with the peptide ligand Gly-Pro-Arg-Pro-amide, 3hus Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Fibrinogen is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, thrombin, exposing Knobs A & B to form fibrin. It is this fibrin that is linked to clotting factors like factor XIII which form clots to prevent excessive bleeding from wounds sustained.

3D Structure of Fibrinogen

Fibrinogen is composed of 3 non-identical chains alpha, beta, gamma (Fba, Fbb, Fbg) .

Fibrinogen alpha+beta+gamma chains

3hus, 3h32, 3e1i, 3bvh, 2hlo, 2hod, 2hpc, 2oyh, 2oyi, 2h43, 2ffd, 1re3, 1rf1, 1n86, 1ltj – hFba+hFbb+hFbg+peptide ligand – human
3ghg, 2q9i, 2z4e - hFba+hFbb+hFbg+knob A & B
2a45 - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor
1re4, 1rf0, 1n8e, 1lt9 - hFba+hFbb+hFbg
1jy3, 1deq – cFba+cFbb+cFbg - cow
1n73, 1lwu - Fba+Fbb+Fbg+peptide ligand – Sea lamprey
1m1j - heFba+heFbb+heFbg+peptide ligand – hen
1ei3 - heFba+heFbb+heFbg

Fibrinogen alpha chain

1fzd – hFba EC domain
2jor – cFba – NMR
2baf – cFba

Fibrinogen beta chain

1fzf, 1fzg – hFb fragment double-D +peptide ligand
1fze, 1fza, 1fzb – hFb fragment D

Fibrinogen gamma chain

2vr3 – hFbg+SaClumping Factor A – Staphylococcus aureus
2vdo, 2vdp, 2vdq, 2vdr – hFbg+Integrin alpha IIB+Integrin beta-3+Monoclonal antibody heavy and light chains
2fib, 3fib - hFbg+peptide ligand
1fib – hFbg+Ca
1fic, 1fid - hFbg