3mf5

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Image:3mf5.jpg

Template:STRUCTURE 3mf5

Hepatitis C virus polymerase NS5B (BK) with amide bioisostere thumb site inhibitor

Template:ABSTRACT PUBMED 20584604

About this Structure

3MF5 is a 2 chains structure with sequences from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

  • Yang H, Hendricks RT, Arora N, Nitzan D, Yee C, Lucas MC, Yang Y, Fung A, Rajyaguru S, Harris SF, Leveque VJ, Hang JQ, Pogam SL, Reuter D, Tavares GA. Cyclic amide bioisosterism: strategic application to the design and synthesis of HCV NS5B polymerase inhibitors. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4614-9. Epub 2010 Jun 8. PMID:20584604 doi:10.1016/j.bmcl.2010.06.008

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