2ccm

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spinqualitylabelsall models 2ccm, resolution 1.8Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

X-RAY STRUCTURE OF CALEXCITIN FROM LOLIGO PEALEII AT 1.8A

Overview

The three-dimensional structure of the neuronal calcium-sensor protein, calexcitin from Loligo pealei has been determined by X-ray analysis at a, resolution of 1.8A. Calexcitin is up-regulated following Pavlovian, conditioning and has been shown to regulate potassium channels and the, ryanodine receptor. Thus, calexcitin is implicated in neuronal excitation, and plasticity. The overall structure is predominantly helical and compact, with a pronounced hydrophobic core between the N and C-terminal domains of, the molecule. The structure consists of four EF-hand motifs although only, the first three EF hands are involved in binding calcium ions; the, C-terminal EF-hand lacks the amino acids required for calcium binding. The, overall structure is quite similar to that of the sarcoplasmic, ... [(full description)]

About this Structure

2CCM is a [Single protein] structure of sequence from [Loligo plei] with CA as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Structure of the neuronal protein calexcitin suggests a mode of interaction in signalling pathways of learning and memory., Erskine PT, Beaven GD, Hagan R, Findlow IS, Werner JM, Wood SP, Vernon J, Giese KP, Fox G, Cooper JB, J Mol Biol. 2006 Apr 14;357(5):1536-47. Epub 2006 Feb 8. PMID:16497326

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