Elastase

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Crystal structure of full-length human Elastase (Metalloproteinase-12), 3ba0

Elastase (ELA) is a chymotrypsin-like protease which breaks down proteins. The ELAs are numbered according to their genes. ELA2 (or PMN-ELA) is secreted by neutrophils during inflammation. The images at the left and at the right correspond to one representative Elastase structure, i.e. human Matrix Metalloproteinase-12 (MMP12), which is macrophage ELA (3ba0).

1 MMP12
2 MMP16
3 ELA
4 ELA2

MMP12

3lka - hMMP12 catalytic domain+hydroxamic acid+paramethoxy-sulfonyl amide – human
3ba0, 1jk3 – hMMP12
3ehx, 3ehy, 1utt, 1utz, 1ros - hMMP12 catalytic domain+inhibitor
2oxu - hMMP12 catalytic domain
2oxw, 2oxz - hMMP12 catalytic domain+peptide
2hu6 - hMMP12 catalytic domain+bicyclic inhibitor
1rmz - hMMP12 catalytic domain+ inhibitor NNGH
1y93 - hMMP12 catalytic domain+acetohydroxamic acid
1jiz – hMMP12+ hydroxamic acid
1os2 - hMMP12 (mutant)+hydroxamic acid
1os9 - hMMP12 (mutant)
3f15, 3f16, 3f17, 3f18, 3f19, 3f1a - hMMP12 catalytic domain+sulfonamide inhibitor
2w0d - hMMP12 catalytic domain (mutant)
2krj, 2k9c – hMMP12 fraction – NMR
2jxy - hMMP12 hemopexin-like domain – NMR
2k2g - hMMP12 catalytic domain+inhibitor – NMR
2poj - hMMP12 catalytic domain – NMR
2z2d - hMMP12 catalytic domain+butanoic acid – NMR
1ycm, 1z3j – hMMP12 (mutant)+hydroxamic acid derivative - NMR
2wo8, 2wo9, 2woa – hMMP12 fraction+hydroxy carboxylic acid

MMP16

1rm8 – hMMP16+batimastat

ELA

3mty, 3mu0, 3mu1, 3mu4, 3mu5, 3mu8, 3mnb, 3mnc, 3mns, 3mnx, 3mo3, 3mo6, 3mo9, 3moc, 3e3t, 2v0b, 2g4t, 2g4u, 2de8, 2blo, 2blq, 2a7c, 2a7j, 1gvk, 1qnj, 1lvy, 3est, 1est – pELA1 – pig
3hgn – pELA1+peptidyl inhibitor – neutron
3hgp, 2cv3, 2bdb, 2bcd, 2h1u, 1mmj, 1h9l, 1nes, 4est, 5est, 8est, 7est - pELA1+peptidyl inhibitor
1fzz – pELA1+ONO-6818
1qr3, 1qgf, 1bru, 1hv7, 1btu – pELA1+cyclic inhibitor
1e34, 1e35, 1e36, 1e37, 1e38 – pELA1-gamma-lactam
1eai – pELA1+Ascaris inhibitor
1fle – pELA1+elafin
1b0e, 1b0f – pELA1+MDL
2v35 – pELA1+JM54
2iot – pELA1+clavulanic acid
2de9 – pELA1+tris
1uvo, 1uvp, 1lka, 1lkb – pELA1+ions
1gwa – pELA1+I3
1uo6, 1c1m – pELA1+Xe
1l0z, 1l1g - pELA1+Xe+Br
2bb4, 2bd2, 2bd3, 2bd4, 2bd5, 2bd7, 2bd8, 2bd9, 1hax, 1hay, 1haz, 1hb0, 1qix – pELA1+beta-casomorphin-7
2bda – pELA1+N-acetyl-NPI
1mcv – pELA1+squash inhibitor
1bma – pELA1+aminimide
1elf, 1elg – pELA1+peptidyl hydroxylamine
1eld, 1ele, 1elb, 1ela, 1elc, 2est – pELA1+anilide inhibitor
1esa, 1esb – pELA1 intermediate
1eas, 1eat, 1eau – pELA1+pyridine inhibitor
1inc – pELA1+benzoxazinone
1jim, 9est, 8est – pELA1+coumarin derivative
2fo9, 2foa, 2fob, 2foc, 2fod, 2foe, 2fof, 2fog, 2foh – pELA1+solvent
3dbk – PaELA+phophoramidon – Pseudomonas aeruginosa
1u4g – PaELA+HPI
1ezm - PaELA
1elt – ELA - salmon