3o5x

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Image:3o5x.jpg

Template:STRUCTURE 3o5x

Crystal structure of the oncogenic tyrosine phosphatase SHP2 complexed with a salicylic acid-based small molecule inhibitor

Template:ABSTRACT PUBMED 20170098

About this Structure

3O5X is a 1 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 3jrl. Full crystallographic information is available from OCA.

Reference

  • Zhang X, He Y, Liu S, Yu Z, Jiang ZX, Yang Z, Dong Y, Nabinger SC, Wu L, Gunawan AM, Wang L, Chan RJ, Zhang ZY. Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2). J Med Chem. 2010 Feb 19. PMID:20170098 doi:10.1021/jm901645u

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