1gzs

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spinqualitylabelsall models 1gzs, resolution 2.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE GEF DOMAIN OF THE SALMONELLA TYPHIMURIUM SOPE TOXIN AND HUMAN CDC42

Overview

The bacterial enteropathogen Salmonella typhimurium employs a type III, secretion system to inject bacterial toxins into the host cell cytosol., These toxins transiently activate Rho family GTP-binding protein-dependent, signaling cascades to induce cytoskeletal rearrangements. One of these, translocated Salmonella toxins, SopE, can activate Cdc42 in a Dbl-like, fashion despite its lack of sequence similarity to Dbl-like proteins, the, Rho-specific eukaryotic guanine nucleotide exchange factors. To elucidate, the mechanism of SopE-mediated guanine nucleotide exchange, we have, analyzed the structure of the complex between a catalytic fragment of SopE, and Cdc42. SopE binds to and locks the switch I and switch II regions of, Cdc42 in a conformation that promotes guanine nucleotide release. ... [(full description)]

About this Structure

1GZS is a [Protein complex] structure of sequences from [Homo sapiens] and [Salmonella typhimurium] with SO4 as [ligand]. Structure known Active Site: SA1. Full crystallographic information is available from [OCA].

Reference

Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE., Buchwald G, Friebel A, Galan JE, Hardt WD, Wittinghofer A, Scheffzek K, EMBO J. 2002 Jul 1;21(13):3286-95. PMID:12093730

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