3nww

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Image:3nww.jpg

Template:STRUCTURE 3nww

P38 Alpha kinase complexed with a 2-aminothiazol-5-yl-pyrimidine based inhibitor

Template:ABSTRACT PUBMED 20732813

About this Structure

3NWW is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Lin S, Wrobleski ST, Hynes J Jr, Pitt S, Zhang R, Fan Y, Doweyko AM, Kish KF, Sack JS, Malley MF, Kiefer SE, Newitt JA, McKinnon M, Trzaskos J, Barrish JC, Dodd JH, Schieven GL, Leftheris K. Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38alpha MAP kinase inhibitors. Bioorg Med Chem Lett. 2010 Jul 30. PMID:20732813 doi:10.1016/j.bmcl.2010.07.102

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