3jsd

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Image:3jsd.jpg

Template:STRUCTURE 3jsd

Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus

About this Structure

3JSD is a 4 chains structure. Full crystallographic information is available from OCA.

Reference

  • Baker EN, Blundell TL, Cutfield JF, Cutfield SM, Dodson EJ, Dodson GG, Hodgkin DM, Hubbard RE, Isaacs NW, Reynolds CD, et al.. The structure of 2Zn pig insulin crystals at 1.5 A resolution. Philos Trans R Soc Lond B Biol Sci. 1988 Jul 6;319(1195):369-456. PMID:2905485
  • Bentley G, Dodson E, Dodson G, Hodgkin D, Mercola D. Structure of insulin in 4-zinc insulin. Nature. 1976 May 13;261(5556):166-8. PMID:1272390
  • Derewenda U, Derewenda Z, Dodson EJ, Dodson GG, Reynolds CD, Smith GD, Sparks C, Swenson D. Phenol stabilizes more helix in a new symmetrical zinc insulin hexamer. Nature. 1989 Apr 13;338(6216):594-6. PMID:2648161 doi:http://dx.doi.org/10.1038/338594a0
  • Hua QX, Nakagawa S, Hu SQ, Jia W, Wang S, Weiss MA. Toward the active conformation of insulin: stereospecific modulation of a structural switch in the B chain. J Biol Chem. 2006 Aug 25;281(34):24900-9. Epub 2006 Jun 8. PMID:16762918 doi:http://dx.doi.org/10.1074/jbc.M602691200

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