Cadherin
From Proteopedia
Cadherins (CDH) are calcium-dependent adhesion proteins. They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions. They are encoded by numerous genes numbered CDH1-CDH23. Some names of CDH indicate their locations: E-CDH (epithelial tissue), T-CDH bound to membrane, N-CDH (neurons). The CDH superfamily contains protocadhedrins (Prot-CDH), desmogleins (Des-CDH) and more. The images at the left and at the right correspond to one representative Cadherin, i.e. the crystal structure of Cadherin (1q1p). Calcium ions is shown as a space filling objects.
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3D Structures of Cadherin
CDH encoded by CDH1
1q1p – mCDH1 - mouse
CDH encoded by CDH5
2koh – mCDH5+PAR3-PDZ3
CDH encoded by CDH6
3lnd – mCDH6 EC12 (mutant)
CDH encoded by CDH8
1zxk – mCDH8 EC1 2a62 - mCDH8 EC1+EC2+EC3
CDH encoded by CDH11
2a4c, 2a4e – mCDH11 EC1
CDH encoded by CDH20
1zvn – cCDH20 EC1 – chicken
CDH encoded by CDH23
3mvs, 2whv – mCDH23 N-terminal 2kbr – hCDH23 peptide+harmonin – NMR - human 2kbs - hCDH23 C-terminal peptide+harmonin PDZ2 – NMR
C-CDH “classical”
1l3w – XlC-CDH ectodomain - Xenopus laevis 1q5b, 1q5c – C-CDH model into desmosome – electron tomography
E-CDH epithelial
1ff5 – mE-CDH double domain 1edh - mE-CDH EC1+EC2+Ca 1suh – mE-CDH N-terminal - NMR 3l6x, 3l6y, 1i7x, 1i7w – mE-CDH+catenin 3lne, 3lnf, 3lng, 3lnh, 3lni – mE-CDH EC12 (mutant) 3ifq – hE-CDH EC1+EC2+EC3 2o72 - hE-CDH EC1+EC2 3ff7, 3ff8 - hE-CDH EC1+EC2+EC3+NK cell receptor 2qvf – mE-CDH1 CDH2 2omt, 2omu, 2omx, 2omz, 2omv, 2omw, 2omy – hE-CDH EC1+internalin (mutant) 1o6s – E-CDH N-terminal+internalin – Listeria monocytogenes
T-CDH membrane bound
3k5r – mT-CDH EC1+EC2 3k5s - cT-CDH EC1+EC2 3k6d - XlT-CDH EC1 3k6f - mT-CDH EC1 3k6i - cT-CDH EC1 2v37 – hT-CDH N-terminal - NMR
N-CDH neuronal
1nch, 1nci – mN-CDH 1ncg – mN-CDH (mutant) 2qvi – mN-CDH EC12 1ncj – mN-CDH two domains
Protocadherin
2yst – hProt-CDH7 EC3 – NMR
Desmoglein
2yqg – hDes-CDH EC1
