2w2q

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Image:2w2q.png

Template:STRUCTURE 2w2q

PCSK9-DELTAC D374H MUTANT BOUND TO WT EGF-A OF LDLR

Template:ABSTRACT PUBMED 19001363

About this Structure

2W2Q is a 3 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Bottomley MJ, Cirillo A, Orsatti L, Ruggeri L, Fisher TS, Santoro JC, Cummings RT, Cubbon RM, Lo Surdo P, Calzetta A, Noto A, Baysarowich J, Mattu M, Talamo F, De Francesco R, Sparrow CP, Sitlani A, Carfi A. Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants. J Biol Chem. 2009 Jan 9;284(2):1313-23. Epub 2008 Nov 10. PMID:19001363 doi:10.1074/jbc.M808363200

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