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1z6e

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Revision as of 04:37, 29 September 2010 by OCA (Talk | contribs)
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Image:1z6e.png

Template:STRUCTURE 1z6e

Factor XA in complex with the inhibitor 1-(3'-amino-1,2-benzisoxazol-5'-yl)-n-(4-(2'-((dimethylamino)methyl)-1h-imidazol-1-yl)-2-fluorophenyl)-3-(trifluoromethyl)-1h-pyrazole-5-carboxamide (razaxaban; DPC906; BMS-561389)

Template:ABSTRACT PUBMED 15771420

About this Structure

1Z6E is a 2 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Quan ML, Lam PY, Han Q, Pinto DJ, He MY, Li R, Ellis CD, Clark CG, Teleha CA, Sun JH, Alexander RS, Bai S, Luettgen JM, Knabb RM, Wong PC, Wexler RR. Discovery of 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2'-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide hydrochloride (razaxaban), a highly potent, selective, and orally bioavailable factor Xa inhibitor. J Med Chem. 2005 Mar 24;48(6):1729-44. PMID:15771420 doi:10.1021/jm0497949

Page seeded by OCA on Wed Sep 29 07:47:10 2010

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