3oaw

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Image:3oaw.png

Template:STRUCTURE 3oaw

4-Methylpteridineones as Orally Active and Selective PI3K/mTOR Dual Inhibitors

Template:ABSTRACT PUBMED 20817449

About this Structure

3OAW is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Liu KK, Bagrodia S, Bailey S, Cheng H, Chen H, Gao L, Greasley S, Hoffman JE, Hu Q, Johnson TO, Knighton D, Liu Z, Marx MA, Nambu MD, Ninkovic S, Pascual B, Rafidi K, Rodgers CM, Smith GL, Sun S, Wang H, Yang A, Yuan J, Zou A. 4-Methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6096-9. Epub 2010 Aug 14. PMID:20817449 doi:10.1016/j.bmcl.2010.08.045

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