2vb2

From Proteopedia

Revision as of 09:13, 23 January 2008 by OCA (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
Image:2vb2.jpg

2vb2, resolution 1.70Å

Drag the structure with the mouse to rotate

CRYSTAL STRUCTURE OF CU(I)CUSF

Overview

Methionine-rich motifs have an important role in copper trafficking, factors, including the CusF protein. Here we show that CusF uses a new, metal recognition site wherein Cu(I) is tetragonally displaced from a, Met2His ligand plane toward a conserved tryptophan. Spectroscopic studies, demonstrate that both thioether ligation and strong cation-pi interactions, with tryptophan stabilize metal binding. This novel active site chemistry, affords mechanisms for control of adventitious metal redox and, substitution chemistry.

About this Structure

2VB2 is a Single protein structure of sequence from Escherichia coli with and as ligands. Known structural/functional Sites: and . Full crystallographic information is available from OCA.

Reference

Cu(I) recognition via cation-pi and methionine interactions in CusF., Xue Y, Davis AV, Balakrishnan G, Stasser JP, Staehlin BM, Focia P, Spiro TG, Penner-Hahn JE, O'Halloran TV, Nat Chem Biol. 2008 Feb;4(2):107-9. Epub 2007 Dec 23. PMID:18157124

Page seeded by OCA on Wed Jan 23 11:13:50 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vb2"
Personal tools