2xtj

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Image:2xtj.jpg

Template:STRUCTURE 2xtj

THE CRYSTAL STRUCTURE OF PCSK9 IN COMPLEX WITH 1D05 FAB

Template:ABSTRACT PUBMED 20959675

About this Structure

2XTJ is a 6 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Ni YG, Di Marco S, Condra JH, Peterson LB, Wang W, Wang F, Pandit S, Hammond HA, Rosa R, Cummings RT, Wood DD, Liu X, Bottomley MJ, Shen X, Cubbon RM, Wang SP, Johns DG, Volpari C, Hamuro L, Chin J, Huang L, Zhao JZ, Vitelli S, Haytko P, Wisniewski D, Mitnaul LJ, Sparrow CP, Hubbard B, Carfi A, Sitlani A. A proprotein convertase subtilisin-like/kexin type 9 (PCSK9)-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces free circulating PCSK9 and LDL-cholesterol. J Lipid Res. 2010 Oct 19. PMID:20959675 doi:10.1194/jlr.M011445

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