From Proteopedia

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A large family of over 60,000 proteins feature horseshoe- or arc-shaped domains made of leucine-rich repeats, which are named for a repeated motif that always contains leucine.^[1]

spinqualitylabelsall models PDB ID 3e6j Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
Lamprey Variable Lymphocyte Receptor (3e6j), resolution 1.67Å ()
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

Articles in Proteopedia concerning Leucine-rich repeat proteins include:

• • Human Follicle Stimulating Hormone Complexed with its Receptor
  • Variable Lymphocyte Receptors
  • Lamprey Variable Lymphocyte Receptor

spinqualitylabelsall models PDB ID 1xwd Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1xwd, resolution 2.92Å ()
Ligands:	, ,
Gene:	CGA (Homo sapiens), FSHB (Homo sapiens), FSHR (Homo sapiens)
Structural annotation: Resources: CATH : 1Xwda00, 1Xwdb00, 1Xwdd00, 1Xwde00 InterPro : Ipr000476, Ipr002400, Ipr006208, Ipr001545, Ipr000276, Ipr001611, Ipr002131, Ipr002272, Ipr000372 Pfam : PF00236, PF00007, PF01462, PF00560 UniProt : P01215, P01225, P23945
Functional annotation: Cellular component: extracellular region soluble fraction membrane plasma membrane integral to membrane Biological process: signal transduction cell-cell signaling spermatogenesis Sertoli cell proliferation female gamete generation ovarian follicle development female pregnancy gonad development G-protein coupled receptor protein signaling pathway female gonad development Molecular function: hormone activity follicle-stimulating hormone activity protein heterodimerization activity signal transducer activity protein binding follicle-stimulating hormone receptor activity G-protein coupled receptor activity protein-hormone receptor activity receptor activity rhodopsin-like receptor activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

To view automatically seeded indices concerning Leucine-rich repeat proteins, see:

• • Leucine-rich repeat
  • Leucine-rich-repeat
  • Leucine-rich repeat-containing protein 4
  • LRR
  • Leucine-rich repeat glycoprotein

References

1. ↑ Matsushima N, Miyashita H, Mikami T, Kuroki Y. A nested leucine rich repeat (LRR) domain: the precursor of LRRs is a ten or eleven residue motif. BMC Microbiol. 2010 Sep 9;10:235. PMID:20825685 doi:10.1186/1471-2180-10-235

See Also

• Toll-like receptors (TLRs)

Additional Literature

• Kobe B, Kajava AV. The leucine-rich repeat as a protein recognition motif. Curr Opin Struct Biol. 2001 Dec;11(6):725-32. PMID:11751054
• Matsushima N, Tanaka T, Enkhbayar P, Mikami T, Taga M, Yamada K, Kuroki Y. Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors. BMC Genomics. 2007 May 21;8:124. PMID:17517123 doi:10.1186/1471-2164-8-124
• Matsushima N, Tachi N, Kuroki Y, Enkhbayar P, Osaki M, Kamiya M, Kretsinger RH. Structural analysis of leucine-rich-repeat variants in proteins associated with human diseases. Cell Mol Life Sci. 2005 Dec;62(23):2771-91. PMID:16231091 doi:10.1007/s00018-005-5187-z
• Kajava AV, Kobe B. Assessment of the ability to model proteins with leucine-rich repeats in light of the latest structural information. Protein Sci. 2002 May;11(5):1082-90. PMID:11967365 doi:10.1110/ps.4010102