Toll-like Receptors

From Proteopedia

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Toll-like receptors, often abbreviated TLRs, are critical to the innate immune system. Toll-like receptors of vertebrates and invertebrates recognize molecular patterns associated with pathogens and initiate an intracellular kinase cascade, inducing an immediate defensive response.^[1][2] Template:STRUCTURE 3ciy

 

Articles in Proteopedia concerning Toll-like Receptors include:

• Leucine-rich repeat
• Membrane proteins

To view automatically seeded indices concerning Toll-like Receptors, see:

• Toll pathway
• Toll-like receptor
• Toll-like receptor 10
• Toll
• Toll like receptor adaptor domain
• TLR

Contents 1 References and Notes 2 See Also 3 Additional Literature 4 External Resources

References and Notes

1. ↑ Gong J, Wei T, Zhang N, Jamitzky F, Heckl WM, Rossle SC, Stark RW. TollML: a database of toll-like receptor structural motifs. J Mol Model. 2010 Jul;16(7):1283-9. Epub 2010 Jan 19. PMID:20084417 doi:10.1007/s00894-009-0640-9
2. ↑ Arancibia SA, Beltran CJ, Aguirre IM, Silva P, Peralta AL, Malinarich F, Hermoso MA. Toll-like receptors are key participants in innate immune responses. Biol Res. 2007;40(2):97-112. Epub 2007 Nov 21. PMID:18064347 doi:/S0716-97602007000200001

See Also

• Anitbody
• Leucine-Rich Repeat Proteins

Additional Literature

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• Botos I, Liu L, Wang Y, Segal DM, Davies DR. The toll-like receptor 3:dsRNA signaling complex. Biochim Biophys Acta. 2009 Sep-Oct;1789(9-10):667-74. Epub 2009 Jul 9. PMID:19595807 doi:10.1016/j.bbagrm.2009.06.005
• Satake H, Sasaki N. Comparative overview of toll-like receptors in lower animals. Zoolog Sci. 2010 Feb;27(2):154-61. PMID:20141420 doi:10.2108/zsj.27.154
• Matsushima N, Tanaka T, Enkhbayar P, Mikami T, Taga M, Yamada K, Kuroki Y. Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors. BMC Genomics. 2007 May 21;8:124. PMID:17517123 doi:10.1186/1471-2164-8-124
• Carpenter S, O'Neill LA. Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins. Biochem J. 2009 Jul 29;422(1):1-10. PMID:19627256 doi:10.1042/BJ20090616
• Choe J, Kelker MS, Wilson IA. Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science. 2005 Jul 22;309(5734):581-5. Epub 2005 Jun 16. PMID:15961631
• Gong J, Wei T, Zhang N, Jamitzky F, Heckl WM, Rossle SC, Stark RW. TollML: a database of toll-like receptor structural motifs. J Mol Model. 2010 Jul;16(7):1283-9. Epub 2010 Jan 19. PMID:20084417 doi:10.1007/s00894-009-0640-9
• Jin MS, Lee JO. Structures of the toll-like receptor family and its ligand complexes. Immunity. 2008 Aug 15;29(2):182-91. PMID:18701082 doi:10.1016/j.immuni.2008.07.007

External Resources

• TOLLML Database: database of toll-like receptor structural motifs