Cyclooxygenase

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Structure

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NSAIDs

Table X: Selectivity of some NSAIDs

Drug	Coefficient of selectivity (IC50Cox-1/IC50Cox-2)
Ketorolac	100-1000
Naproxen	1-10
Ibuprofen	1-10
Indometacin	1-10
Acetylsalicylic acid	1
Diclofenac	1-0.1
Valdecoxib	0.01-0.001
Etoricoxib	0.01-0.001

Table X: Chemical variety of NSAIDs

Pharmacologic group	Drug
Salicylates	Acetylsalicylic acid
Propionic	Naproxen
	Ibuprofen
Para-aminophenols	Paracetamol
Indolacetic	Indometacin
Pirrolacetic	Ketorolac
Phenilacetic	Diclofenac
Piranoidacetic	Etodolac
Anthranilic	Mefenamic acid
Nicotinic	Clonixin
Sulfonanilides	Nimesulide

Reference

• Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. Epub 2006 Oct 23. PMID:17060607

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• Ghosh N, Chaki R, Mandal V, Mandal SC. COX-2 as a target for cancer chemotherapy. Pharmacol Rep. 2010 Mar-Apr;62(2):233-44. PMID:20508278

• Smith WL, DeWitt DL, Garavito RM. Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem. 2000;69:145-82. PMID:10966456 doi:10.1146/annurev.biochem.69.1.145

• Rang HP, Dale MM, Ritter JM, Flower RJ. 2008. Pharmacology. Elsevier. 6th edition. 844 p.

• Smith WL, Langenbach R. Why there are two cyclooxygenase isozymes. J Clin Invest. 2001 Jun;107(12):1491-5. PMID:11413152 doi:10.1172/JCI13271

• Chandrasekharan NV, Dai H, Roos KL, Evanson NK, Tomsik J, Elton TS, Simmons DL. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13926-31. Epub 2002 Sep 19. PMID:12242329 doi:10.1073/pnas.162468699