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Template:STRUCTURE 3hbt

Actin is a protein found in all eukaryotic cells. It is the monomer of two types of filaments: microfilaments which are part of the cytoskeleton and thin filaments which are part of muscles. Three isoforms of actin are identified: Alpha (Aa) (or G-actin) found in muscle tissue, beta (Ab) and gamma (Ag) actins are components of the cytoskeleton. F-actin is Aa bound to ATP. The images at the left and at the right correspond to one representative Actin, i.e. the crystal structure of rabbit Native G-actin (3hbt).

3D Structures of Actin

Alpha actin 1 (Aa)

2w49 – cAa +troponin C+ troponin T+ troponin I+ tropomyocin alpha-1 – chicken
1mdu – cAa+hGelsolin
3hbt, 2zwh, 1nwk, 1j6z – rAa – rabbit
2q1n, 2q31, 2a5x, 1rdw, 1rfq, 1lcu – rAa – dimer
2q36, 1qz5 – rAa+kabiramide C – dimer
2hmp – rAa – protease cleaved
2zwh, 2gwj, 2gwk – rAa-ATP
2vyp – rAa+myxobacterial rhizopodin
2v51, 2v52 – rAa+mMKL/Myocardin-like protein – mouse (m)
2vcp – rAa+ neural wiskott-aldrich syndrome protein (hWASP) – human (h)
2a3z, 2a40, 2a41 – rAa+cDNase I+domains of hWASP – cow (c)
2ff3 - rAa+ hGelsolin +domains of hWASP
2a42 – rAa+cDNase I
3daw – rAa+mTwinfilin-1
3buz – rAa+Iota toxin component IA
3b5u – rAa filament – fiber diffraction
1eqy, 3cjb, 1p8z – rAa+hGelsolin
1rgi - rAa+hoGelsolin – horse (ho)
1t44 - rAa+hGelsolin:mThymosin B4
1esv - rAa+hGelsolin+ latrunculin A
3cjc - rAa+hGelsolin+cDNase I
2d1k - rAa+hWH2 domain of MIN+cDNase I
2pbd – rAa+hProfilin-1
2pav - rAa+hProfilin-1+hVASP
2q97 – rAa+toxofilin – Toxoplasma gondii
2q0r – rAa+pectenotoxin-2
2q0u - rAa+pectenotoxin-2+latrunculin B
1ijj - rAa+latrunculin A
2fxu – rAa+bistramide A
1wua – rAa+alpyronine A
2asm, 2asp – rAa+reidispongiolide
2aso – rAa+sphinxolide B
1yxq – rAa+swinholide A
1y64 – rAa+yBNI1 domain FH2 - yeast
1sqk – rAa+DmCiboulot - Drosophila melanogaster (Dm)
2ff6 - rAa+DmCiboulot+hGelsolin
1s22 – rAa+ulapualide A
1qz6 – rAa+jaspisamide A
1lot, 1kxp, 1ma9 – rAa+hVitamin D binding protein

Beta actin (Ab)

3lue – hAb+hAlpha-actinin
3byh – hAb+hFimbrin ABD2 – Cryo EM
2oan – cAb

Gamma 1 actin (Ag)

1atn – rAg+cDNase I
3chw – Major DdAg+hProfilin+poly-Pro repeat – Dictyostelium discoideum
3ci5, 3cip, 1nmd - Major DdAg+hGelsolin
1c0g, 1dej – DdAg:tetrahymenatA+hGelsolin
1nm1 - DdAg+hGelsolin+Mg-ATP
1nlv, 1c0f – DdAg+hGelsolin
1d4x – Ag 1/3+hGelsolin – C. elegans
1h1v – hAg+rGelsolin
1hlu, 2btf – cA+cProfilin
1o1g, 1o1a, 1o1b, 1o1c, 1o1d, 1o1e, 1o1f, 1o18, 1o19, 1mvw, 1m8q –cAg+cMyosin II - tomography
3eks – DmAg 5c (mutant)
3eku – DmAg 5c (mutant)+cytochalasin D
3el2, 2hf4 - DmAg 5c (mutant)+Ca-ATP
2hf3 - DmAg 5c (mutant)+Ca-ADP
3b63 – actin filament – Limulus polyphemus
1yvn – yA (mutant)+hGelsolin
1yag - yA+hGelsolin