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Tositumomab

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Pharmacokinetics

Anti-CD20 Monoclonal Antibody Pharmacokinetics [1]
Parameter Tositumomab Ofatumumab Rituximab Ibritumomab
Tmax (hr) Tositumomab 7.6 Rituximab Ibritumomab
Cmax (ng/ml) Tositumomab 167000 205800 67000
Bioavailability (%) Tositumomab Ofatumumab Rituximab Ibritumomab
T1/2 (hr) 64.8 68 206 108
AUC (ng/ml/hr) Tositumomab 32939000 Rituximab 17000
Clearance (L/h) .078 .017 .009 Ibritumomab
IC50 (nM) Tositumomab Ofatumumab Rituximab Ibritumomab
Dosage Tositumomab 500 mg (4th Infusion) 325 mg/m2 (4th Infusion) Ibritumomab
Metabolism Tositumomab Ofatumumab Rituximab Ibritumomab

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