3oy3

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Image:3oy3.jpg

Template:STRUCTURE 3oy3

Crystal structure of ABL T315I mutant kinase domain bound with a DFG-out inhibitor AP24589

Template:ABSTRACT PUBMED 21118377

About this Structure

3OY3 is a 2 chains structure with sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Zhou T, Commodore L, Huang WS, Wang Y, Thomas M, Keats J, Xu Q, Rivera VM, Shakespeare WC, Clackson T, Dalgarno DC, Zhu X. Structural Mechanism of the Pan-BCR-ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibitor Resistance. Chem Biol Drug Des. 2011 Jan;77(1):1-11. doi:, 10.1111/j.1747-0285.2010.01054.x. Epub 2010 Nov 30. PMID:21118377 doi:10.1111/j.1747-0285.2010.01054.x

Page seeded by OCA on Wed Dec 15 08:44:23 2010

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